Plague - Florida Health. Disease Control. [email protected]. 850-245-4444. Florida Health. 4052 Bald Cypress Way. Tallahassee, FL 32399. Plague is an acute, bacterial disease caused by Yersinia pestis, a Gram-negative bacteria that is transmitted from rodent to rodent by infected fleas.

 
Sep 24, 2020 · History of Plague Epidemics. The plague has afflicted humanity for thousands of years.1, 2, 3 Molecular studies identified the presence of the Y. pestis plague DNA genome in 2 Bronze Age skeletons dated at roughly 3800 years old. 9 In the biblical book 1 Samuel from approximately 1000 BCE, the Philistines experience an outbreak of tumors associated with rodents, which might have been bubonic ... . The butcher

Bubonic plague is one of three types of plague caused by the bacterium Yersinia pestis. [1] One to seven days after exposure to the bacteria, flu-like symptoms develop. [1] These symptoms include fever, headaches, and vomiting, [1] as well as swollen and painful lymph nodes occurring in the area closest to where the bacteria entered the skin. [2] Jun 15, 2023 · The disease is most common in parts of Africa, Asia and South America, but it also occurs in some areas of the western United States. Symptoms can include an abrupt onset of chills, fever, and enlarged, painful lymph nodes (buboes). Most cases of plague resolve with effective treatment, though treatment must be started immediately to avoid life ... Jul 22, 2021 · The 10-year-old child who died of plague earlier this month was a La Plata County resident. Plague is caused by bacteria and usually is transmitted by bites from infected fleas. Prairie dogs ... Jul 23, 2021 · The plague is treatable in humans and animals if caught and addressed early. CBSN Denver noted that last year, two people in Colorado were confirmed to have contracted the plague, and both survived. Plagues of Egypt. Scenes from the book of Exodus: The death of the firstborns (including the Pharaoh 's son), and the Israelites leaving Egypt ( Haggadah shel Pesaḥ, 1325–1374 CE, Barcelona via British Library) The Plagues of Egypt, in the account of the book of Exodus, are ten disasters inflicted on Biblical Egypt by the God of Israel in ...3. The Italian Plague of 1629-31. Even after the Black Death ended, the bubonic plague continued to sporadically rear its ugly head in Europe for several centuries. One of the most calamitous ...Pneumonic plague transmission Although plague can sometimes spread from person to person, this is rare.1 A person who has pneumonia caused by plague may cough up droplets that contain plague bacteria. These bacteria-containing droplets can cause pneumonic plague if they are breathed in by another person nearby. plague翻译：不斷困擾;折磨;使受煎熬, （尤指因不停提問而）使煩惱，打攪, 瘟疫。了解更多。Oct 29, 2020 · Plague is a serious infectious disease that affects mammals, including humans. It can spread through animal or human contact. The bacteria that cause plague live in many parts of the world ... Oct 1, 2021 · Plague is endemic in Madagascar and outbreaks occur regularly, although every outbreak is cause for concern. Furthermore, pneumonic plague is a notifiable disease under the International Health Regulations 2005. By the following day, 30 August, 25 suspected cases of pneumonic plague had been notified to the health authorities from Arivonimamo ... Synonyms for PLAGUE: afflict, persecute, torture, besiege, curse, attack, beset, torment; Antonyms of PLAGUE: help, aid, assist, relieve, release, deliver, abet, comfort Play Plague Inc. Online in Browser. Plague Inc. is a simulation game developed by Miniclip.com and now.gg allows playing game online in your browser. There are many more interesting online games that you can explore here. READ MORE FAQs.Synonyms for PLAGUE: afflict, persecute, torture, besiege, curse, attack, beset, torment; Antonyms of PLAGUE: help, aid, assist, relieve, release, deliver, abet, comfortplague ý nghĩa, định nghĩa, plague là gì: 1. to cause worry, pain, or difficulty to someone or something over a period of time: 2. to annoy…. Tìm hiểu thêm.“[Blurbs] are a PLAGUE on this industry” said Lucy Carson (emphasis her own), a literary agent at The Friedrich Agency who has worked with literary bigwigs like Pulitzer Prize-winner Elizabeth ...“[Blurbs] are a PLAGUE on this industry” said Lucy Carson (emphasis her own), a literary agent at The Friedrich Agency who has worked with literary bigwigs like Pulitzer Prize-winner Elizabeth ...Pneumonic plague is the most serious form of the disease and the only form that can spread from person to person. As a result of a bioterrorist attack, sick people would likely be seen outside the areas where plague naturally occurs due to the potential for release in other areas and person-to-person spread between close contacts. Plague: Directed by Nick Kozakis, Kosta Ouzas. With Don Bridges, Cris Cochrane, Tegan Crowley, Liza Dennis. A small group of survivors in post-apocalyptic Australia seek shelter from an infection that has spread like a plague among the human populace.Jul 7, 2022 · Plague is an infectious disease caused by the bacteria Yersinia pestis, a zoonotic bacteria, usually found in small mammals and their fleas. It is transmitted between animals through fleas. Humans can be infected through: the bite of infected vector fleas. unprotected contact with infectious bodily fluids or contaminated materials. plague n. (infestation of insects or rats) invasion nf. (de moustiques, sauterelles,...) nuée nf. The citizens of Hamlin called on the services of the Pied Piper because of a plague of rats. Les citoyens de la ville de Hamelin ont fait appel au service du joueur de flûte à cause d'une invasion de rats. plague n. New plague vaccines are in development but are not expected to be commercially available in the immediate future. Page last reviewed: November 27, 2018 Content source: Centers for Disease Control and Prevention , National Center for Emerging and Zoonotic Infectious Diseases (NCEZID) , Division of Vector-Borne Diseases (DVBD)Nov 22, 2022 · Explore the history of the European plague doctor, and find out where their iconic outfit of a beaked mask and robe came from.--The year is 1656. Your body i... Nov 15, 2021 · Septicemic plague can occur as the first symptom of plague or may develop from untreated bubonic plague. This form results from bites of infected fleas or from handling an infected animal. Pneumonic plague: The incubation period of pneumonic plague is usually just 1 to 3 days. Patients develop fever, headache, weakness, and a rapidly developing ... Define plague. plague synonyms, plague pronunciation, plague translation, English dictionary definition of plague. ) n. 1. a. A highly infectious epidemic disease ... Septicemic plague (Black Death or black plague) symptoms and signs include fever, weakness, abdominal pain, chills, and shock. Tissue bleeding and death may cause the dying tissues to appear black. Pneumonic plague symptoms and signs include characteristic pneumonia symptoms like chest pain, shortness of breath, cough, fever, chills, nausea ...Aug 23, 2023 · Plague Inc. is a unique mix of high strategy and terrifyingly realistic simulation. Your pathogen has just infected 'Patient Zero'. Now you must bring about the end of human history by evolving a deadly, global Plague whilst adapting against everything humanity can do to defend itself. Brilliantly executed with innovative gameplay and built ... The Black Death of 1347-1352 CE is the most infamous plague outbreak of the medieval world, unprecedented and unequaled until the 1918-1919 CE flu pandemic in the modern age. The cause of the plague was unknown and, in accordance with the general understanding of the Middle Ages, was attributed to supernatural forces and, primarily, the will or ...In a plague emergency, CDC and other federal agencies would work closely with state and local partners to coordinate a response. CDC and other federal agencies would respond by: Coordinating activities through the Emergency Operations Center. Communicating information about plague to the public. Providing guidance to healthcare providers ...Apr 20, 2023 · Plague symptoms are sudden and serious. If you are coughing or sneezing, you should wear a mask. You will likely go to an emergency room. If plague is suspected, you'll see a specialist in infectious disease. What you can do. If you are helping a person with plague-like symptoms, you can prepare for the appointment by taking the following steps: Explore the history of the European plague doctor, and find out where their iconic outfit of a beaked mask and robe came from.--The year is 1656. Your body i...Plague Inc: Evolved is a unique mix of high strategy and terrifyingly realistic simulation. Your pathogen has just infected 'Patient Zero' - now you must bring about the end of human history by evolving a deadly, global Plague whilst adapting against everything humanity can do to defend itself. Recent Reviews: Overwhelmingly Positive (361) The plague is a serious bacterial infection that can be deadly. Sometimes referred to as the “black plague,” the disease is caused by a bacterial strain called Yersinia pestis.This bacterium ...The plague as an actual event figures prominently in only one of Shakespeare’s plays. Friar Laurence in “Romeo and Juliet” has asked a fellow friar to deliver a crucial message to the exiled ...Methods. CDC developed these guidelines after reviewing existing data on treatment and prophylaxis of plague, collecting and summarizing additional evidence, and gathering input from approximately 90 experts in numerous fields, including infectious diseases, emergency medicine, pharmacology, neonatology, obstetrics and gynecology, geriatrics, microbiology, epidemiology, and crisis standards of ...Plague is an infectious disease caused by the bacterium Yersinia pestis. Symptoms include fever, weakness and headache. Usually this begins one to seven days after exposure. There are three forms of plague, each affecting a different part of the body and causing associated symptoms.Plague is a febrile illness that typically manifests into one or more clinical syndromes, often reflecting the route of exposure to the bacterium. These clinical syndromes include bubonic, septicemic, and pneumonic plague. Several classes of antibiotics are effective against plague. Plague can be rapidly fatal if appropriate antimicrobial ... Aug 29, 2023 · Plague, infectious disease caused by Yersinia pestis, a bacterium transmitted from rodents to humans by the bite of infected fleas. Plague has caused some of the most-devastating epidemics in history. It was the disease behind the Black Death of the 14th century, when as much as one-third of Europe’s population died. The bubonic plague - named the Black Death by later historians - was caused by the yersinia pestis bacteria, which lived in rodent populations and was spread by fleas that had bitten infected animals. Once the plague transferred to animals that were in close contact with humans and to humans themselves, it began to spread along established ... The Black Death was a bubonic plague pandemic, which reached England in June 1348. It was the first and most severe manifestation of the second pandemic, caused by Yersinia pestis bacteria. The term Black Death was not used until the late 17th century. Originating in Asia, it spread west along the trade routes across Europe and arrived on the ... Mar 26, 2020 · Collection. by Mark Cartwright. published on 26 March 2020. Plagues have swept through humanity ever since communities have gathered together in concentrated groups. In this collection of resources, we look at just some of the pandemics that raged throughout Antiquity and the Middle Ages, from the plague that ripped through Athens in the 5th ... "Plague is a must-read book so revolutionary in its implications that its author courageously faced character assassination and unlawful incarceration to keep her findings from being relegated to the dustbin of medical history. Riveting, if not at times paradigm shifting, this book reveals a dark side to modern medi"Plague is a must-read book so revolutionary in its implications that its author courageously faced character assassination and unlawful incarceration to keep her findings from being relegated to the dustbin of medical history. Riveting, if not at times paradigm shifting, this book reveals a dark side to modern mediIn a plague emergency, CDC and other federal agencies would work closely with state and local partners to coordinate a response. CDC and other federal agencies would respond by: Coordinating activities through the Emergency Operations Center. Communicating information about plague to the public. Providing guidance to healthcare providers ...The Plague. The first outbreak of plague swept across England in 1348-49. It seems to have travelled across the south in bubonic form during the summer months of 1348, before mutating into the ...Pneumonic plague is the most serious form of the disease and the only form that can spread from person to person. As a result of a bioterrorist attack, sick people would likely be seen outside the areas where plague naturally occurs due to the potential for release in other areas and person-to-person spread between close contacts. The Crossword Solver found 60 answers to "plague", 4 letters crossword clue. The Crossword Solver finds answers to classic crosswords and cryptic crossword puzzles. Enter the length or pattern for better results. Click the answer to find similar crossword clues . Enter a Crossword Clue.Black Death, pandemic that ravaged Europe between 1347 and 1351, taking a proportionately greater toll of life than any other known epidemic or war up to that time. The Black Death is widely thought to have been the result of plague, caused by infection with the bacterium Yersinia pestis.The Plague. The first outbreak of plague swept across England in 1348-49. It seems to have travelled across the south in bubonic form during the summer months of 1348, before mutating into the ...Plague is a febrile illness that typically manifests into one or more clinical syndromes, often reflecting the route of exposure to the bacterium. These clinical syndromes include bubonic, septicemic, and pneumonic plague. Several classes of antibiotics are effective against plague. Plague can be rapidly fatal if appropriate antimicrobial ... The bubonic plague was the most commonly seen form during the Black Death, with a mortality rate of 30-75% and symptoms including fever of 38 - 41 °C (101-105 °F), headaches, painful aching joints, nausea and vomiting, and a general feeling of malaise. Of those who contracted the bubonic plague, 4 out of 5 died within eight days. People infected with plague usually develop influenza-like symptoms after an incubation period of 3–7 days. Symptoms include fever, chills, aches, weakness, vomiting and nausea. There are 3 main forms of plague. Bubonic plague is the most common and is caused by the bite of an infected flea.3. The Italian Plague of 1629-31. Even after the Black Death ended, the bubonic plague continued to sporadically rear its ugly head in Europe for several centuries. One of the most calamitous ...Pneumonic plague is the most serious form of the disease and the only form that can spread from person to person. As a result of a bioterrorist attack, sick people would likely be seen outside the areas where plague naturally occurs due to the potential for release in other areas and person-to-person spread between close contacts. Before covid-19, this was the world’s most recent pandemic, infecting as much as 21 percent of the world’s population. Swine flu was a hodgepodge of several different flu strains that had ...Plague is endemic in Madagascar and outbreaks occur regularly, although every outbreak is cause for concern. Furthermore, pneumonic plague is a notifiable disease under the International Health Regulations 2005. By the following day, 30 August, 25 suspected cases of pneumonic plague had been notified to the health authorities from Arivonimamo ...Plague is an infectious disease caused by the bacterium Yersinia pestis. Symptoms include fever, weakness and headache. Usually this begins one to seven days after exposure. There are three forms of plague, each affecting a different part of the body and causing associated symptoms.Plague is a serious infectious disease that affects mammals, including humans. It can spread through animal or human contact. The bacteria that cause plague live in many parts of the world ...Jul 6, 2020 · Bubonic plague, the disease's most common form, refers to telltale buboes—painfully swollen lymph nodes—that appear around the groin, armpit, or neck. The skin sores become black, leading to ... Bubonic plague is one of three types of plague caused by the bacterium Yersinia pestis. [1] One to seven days after exposure to the bacteria, flu-like symptoms develop. [1] These symptoms include fever, headaches, and vomiting, [1] as well as swollen and painful lymph nodes occurring in the area closest to where the bacteria entered the skin. [2] Mar 12, 2020 · In the 17th century, people believed these outfits could purify poisonous air. They were wrong. During the 17th-century European plague, physicians wore beaked masks, leather gloves, and long ... The plague is a serious bacterial infection that can be deadly. Sometimes referred to as the “black plague,” the disease is caused by a bacterial strain called Yersinia pestis.This bacterium ...Apr 16, 2020 · The plague hits Marseille, Paris and Normandy, and then the strain splits, with one strain moving onto the now-Belgian city of Tournai to the east and the other passing through Calais. and Avignon ... Pneumonic plague transmission Although plague can sometimes spread from person to person, this is rare.1 A person who has pneumonia caused by plague may cough up droplets that contain plague bacteria. These bacteria-containing droplets can cause pneumonic plague if they are breathed in by another person nearby.Mar 12, 2020 · In the 17th century, people believed these outfits could purify poisonous air. They were wrong. During the 17th-century European plague, physicians wore beaked masks, leather gloves, and long ... Pneumonic plague transmission Although plague can sometimes spread from person to person, this is rare.1 A person who has pneumonia caused by plague may cough up droplets that contain plague bacteria. These bacteria-containing droplets can cause pneumonic plague if they are breathed in by another person nearby. a. : an epidemic disease causing a high rate of mortality : pestilence. b. : a virulent contagious febrile disease that is caused by a bacterium (Yersinia pestis) and that occurs in bubonic, pneumonic, and septicemic forms. called also black death. 3. a.Plague. Plague, caused by the bacterium Yersinia pestis, is a disease that affects humans and other mammals. People typically get infected after being bitten by a rodent flea that is carrying the bacterium or by handling a plague-infected animal. Although the disease killed millions in Europe during the Middle Ages, antibiotics effectively ...The plague bacteria can be transmitted to humans in the following ways: Flea bites. Plague bacteria are most often transmitted by the bite of an infected flea. During plague epizootics, many rodents die, causing hungry fleas to seek other sources of blood. People and animals that visit places where rodents have recently died from plague are at ...The plague hits Marseille, Paris and Normandy, and then the strain splits, with one strain moving onto the now-Belgian city of Tournai to the east and the other passing through Calais. and Avignon ...Plague Inc. is a unique mix of high strategy and terrifyingly realistic simulation with over 700 million games played! Your pathogen has just infected 'Patient Zero'. Now you must bring about the end of human history by evolving a deadly, global Plague whilst adapting against everything humanity can do to defend itself.Plague is caused by Yersinia pestis bacteria. It can be a life-threatening infection if not treated promptly. Plague has caused several major epidemics in Europe and Asia over the last 2,000 years. Plague has most famously been called "the Black Death" because it can cause skin sores that form black scabs. A plague epidemic in the 14th century ...The Justinian Plague of 541-544 . The first great pandemic of bubonic plague where people were recorded as suffering from the characteristic buboes and septicaemia was the Justinian Plague of 541 CE, named after Justinian I, the Roman emperor of the Byzantine Empire at the time. The epidemic originated in Ethiopia in Africa and spread to ...History of Plague Epidemics. The plague has afflicted humanity for thousands of years.1, 2, 3 Molecular studies identified the presence of the Y. pestis plague DNA genome in 2 Bronze Age skeletons dated at roughly 3800 years old. 9 In the biblical book 1 Samuel from approximately 1000 BCE, the Philistines experience an outbreak of tumors associated with rodents, which might have been bubonic ...List of epidemics and pandemics. 17th-century German "plague panel" depicting the triumph of death. Panels of this kind were placed on the walls of houses to warn against the plague. A plague epidemic raged in Augsburg, Bavaria, between 1632 and 1635. This is a list of the largest known epidemics and pandemics caused by an infectious disease.plague meaning: 1. to cause worry, pain, or difficulty to someone or something over a period of time: 2. to annoy…. Learn more. plague翻译：不斷困擾;折磨;使受煎熬, （尤指因不停提問而）使煩惱，打攪, 瘟疫。了解更多。Synonyms for PLAGUE: afflict, persecute, torture, besiege, curse, attack, beset, torment; Antonyms of PLAGUE: help, aid, assist, relieve, release, deliver, abet, comfortPlague Inc: Evolved is a unique mix of high strategy and terrifyingly realistic simulation. Your pathogen has just infected 'Patient Zero' - now you must bring about the end of human history by evolving a deadly, global Plague whilst adapting against everything humanity can do to defend itself. Recent Reviews: Overwhelmingly Positive (361)Plague is a febrile illness that typically manifests into one or more clinical syndromes, often reflecting the route of exposure to the bacterium. These clinical syndromes include bubonic, septicemic, and pneumonic plague. Several classes of antibiotics are effective against plague. Plague can be rapidly fatal if appropriate antimicrobial ... Over 80% of United States plague cases have been the bubonic form. In recent decades, an average of seven human plague cases have been reported each year (range: 1–17 cases per year). Plague has occurred in people of all ages (infants up to age 96), though 50% of cases occur in people ages 12–45. It occurs in both men and women, though ...Plague - Bubonic, Pneumonic, Septicaemic: Plague is an ancient disease that was described during Classical times as occurring in North Africa and the Middle East. It is sometimes presumed to be the disease behind several historic epidemics, such as the pestilence described as striking the Philistines in the biblical book of 1 Samuel.Oct 29, 2020 · Plague is a serious infectious disease that affects mammals, including humans. It can spread through animal or human contact. The bacteria that cause plague live in many parts of the world ...

The bubonic plague was the most commonly seen form during the Black Death, with a mortality rate of 30-75% and symptoms including fever of 38 - 41 °C (101-105 °F), headaches, painful aching joints, nausea and vomiting, and a general feeling of malaise. Of those who contracted the bubonic plague, 4 out of 5 died within eight days. . Alone season 8 runner up

plague

Florida Health. Disease Control. [email protected]. 850-245-4444. Florida Health. 4052 Bald Cypress Way. Tallahassee, FL 32399. Plague is an acute, bacterial disease caused by Yersinia pestis, a Gram-negative bacteria that is transmitted from rodent to rodent by infected fleas.Septicemic plague (Black Death or black plague) symptoms and signs include fever, weakness, abdominal pain, chills, and shock. Tissue bleeding and death may cause the dying tissues to appear black. Pneumonic plague symptoms and signs include characteristic pneumonia symptoms like chest pain, shortness of breath, cough, fever, chills, nausea ...Explore the history of the European plague doctor, and find out where their iconic outfit of a beaked mask and robe came from.--The year is 1656. Your body i...Feb 28, 2022 · Plague is caused by Yersinia pestis bacteria. It can be a life-threatening infection if not treated promptly. Plague has caused several major epidemics in Europe and Asia over the last 2,000 years. Plague has most famously been called "the Black Death" because it can cause skin sores that form black scabs. A plague epidemic in the 14th century ... Oct 1, 2021 · Plague is endemic in Madagascar and outbreaks occur regularly, although every outbreak is cause for concern. Furthermore, pneumonic plague is a notifiable disease under the International Health Regulations 2005. By the following day, 30 August, 25 suspected cases of pneumonic plague had been notified to the health authorities from Arivonimamo ... Collection. by Mark Cartwright. published on 26 March 2020. Plagues have swept through humanity ever since communities have gathered together in concentrated groups. In this collection of resources, we look at just some of the pandemics that raged throughout Antiquity and the Middle Ages, from the plague that ripped through Athens in the 5th ...Background. There are three types of plague. Most of the sick in 1665-1666 had bubonic plague. This created swellings (buboes) in the lymph nodes found in the armpits, groin and neck. Plague sufferers experienced headaches, vomiting and fever. They had a 30% chance of dying within two weeks. Methods. CDC developed these guidelines after reviewing existing data on treatment and prophylaxis of plague, collecting and summarizing additional evidence, and gathering input from approximately 90 experts in numerous fields, including infectious diseases, emergency medicine, pharmacology, neonatology, obstetrics and gynecology, geriatrics, microbiology, epidemiology, and crisis standards of ...Treatment for plague begins as soon as the health care provider suspects the disease. Treatment is typically done in the hospital. Antibiotics that may be used include the following: Gentamicin. Doxycycline (Monodox, Vibramycin, others). Ciprofloxacin (Cipro). Levofloxacin. Moxifloxacin (Avelox). Chloramphenicol.List of epidemics and pandemics. 17th-century German "plague panel" depicting the triumph of death. Panels of this kind were placed on the walls of houses to warn against the plague. A plague epidemic raged in Augsburg, Bavaria, between 1632 and 1635. This is a list of the largest known epidemics and pandemics caused by an infectious disease. Bubonic plague, the disease's most common form, refers to telltale buboes—painfully swollen lymph nodes—that appear around the groin, armpit, or neck. The skin sores become black, leading to ...The Black Death of 1347-1352 CE is the most infamous plague outbreak of the medieval world, unprecedented and unequaled until the 1918-1919 CE flu pandemic in the modern age. The cause of the plague was unknown and, in accordance with the general understanding of the Middle Ages, was attributed to supernatural forces and, primarily, the will or ...The bubonic plague - named the Black Death by later historians - was caused by the yersinia pestis bacteria, which lived in rodent populations and was spread by fleas that had bitten infected animals. Once the plague transferred to animals that were in close contact with humans and to humans themselves, it began to spread along established ... Bubonic plague: Humans can come into contact with plague when an infected flea bites a person or when materials that have plague bacteria enter through a break (a cut or sore) in a person's skin. This is the most common form of plague. Pneumonic plague: Humans can come into contact with plague when a person breathes in plague bacteria from the air.Plague was present in at least one location in the Islamic world virtually every year between 1500 and 1850. [56] Plague repeatedly struck the cities of North Africa. Algiers lost 30,000–50,000 to it in 1620–1621, and again in 1654–1657, 1665, 1691, and 1740–1742. [57]Aug 29, 2023 · The Latin word also is the source of Old Irish plag (genitive plaige) "plague, pestilence," German Plage, Dutch plaage. Meaning "epidemic that causes many deaths" is from 1540s; specifically in reference to bubonic plague from c. 1600. Modern spelling follows French, which had plague from 15c. Weakened sense of "anything annoying" is from c. 1600. Apr 16, 2020 · The Black Death of 1347-1352 CE is the most infamous plague outbreak of the medieval world, unprecedented and unequaled until the 1918-1919 CE flu pandemic in the modern age. The cause of the plague was unknown and, in accordance with the general understanding of the Middle Ages, was attributed to supernatural forces and, primarily, the will or ... Aug 29, 2023 · The Latin word also is the source of Old Irish plag (genitive plaige) "plague, pestilence," German Plage, Dutch plaage. Meaning "epidemic that causes many deaths" is from 1540s; specifically in reference to bubonic plague from c. 1600. Modern spelling follows French, which had plague from 15c. Weakened sense of "anything annoying" is from c. 1600. The plague as an actual event figures prominently in only one of Shakespeare’s plays. Friar Laurence in “Romeo and Juliet” has asked a fellow friar to deliver a crucial message to the exiled ....

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